Oral NAD+
Daily NAD+ Support. No Needle Required.
What It Treats
How It Works
NMN and NR are NAD+ precursors absorbed through the GI tract and converted to NAD+ via the salvage pathway. Daily dosing sustains elevated NAD+ levels, supporting mitochondrial function, sirtuin activation, and DNA repair on an ongoing basis.
Mechanism of Action
Oral NAD+ precursors like NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are converted into NAD+ through enzymatic pathways in the gut and liver. While oral bioavailability is lower than IV (estimated 20-30%), daily dosing creates a sustained elevation of NAD+ levels that maintains the cellular benefits between IV sessions. A 2022 clinical trial in Science showed that NMN at 250mg daily raised blood NAD+ levels by 38% over 12 weeks — enough to measurably improve muscle insulin sensitivity and cellular metabolism.
Randomized placebo-controlled trial in 48 recreational runners showed NMN supplementation at 300-600mg/day for 6 weeks significantly improved aerobic capacity (VO2max) and ventilatory threshold compared to placebo. The NMN group showed enhanced oxygen utilization during exercise, suggesting improved mitochondrial efficiency in skeletal muscle.
NMN supplementation at 250mg daily for 10 weeks increased blood NAD+ metabolites and improved skeletal muscle insulin sensitivity measured by gold-standard clamp technique. The study confirmed that oral NMN achieves meaningful NAD+ elevation in humans and produces measurable metabolic improvements.
The Results
The oral NAD+ research has matured significantly in recent years. Multiple randomized controlled trials have demonstrated that daily NMN or NR supplementation increases NAD+ metabolites in blood and tissue, improves markers of physical function in older adults, and enhances aerobic capacity in middle-aged recreational runners. A 2022 study in the Journal of the International Society of Sports Nutrition showed NMN supplementation improved oxygen utilization during exercise. Oral NAD+ is ideal as a daily maintenance strategy — the convenience of a capsule with measurable cellular benefits.
First completed human clinical trial of chronic NR supplementation showed 500mg twice daily for 6 weeks was well-tolerated and successfully raised NAD+ levels by approximately 60% in whole blood. The study also observed trends toward reduced blood pressure and arterial stiffness, suggesting cardiovascular benefits from sustained NAD+ elevation.
Ideal For
Patients who want daily NAD+ support between IV sessions, or those who prefer an oral-only approach. Also great as a standalone longevity supplement for adults 35+.
Your Protocol
NMN 250-500mg daily (sublingual or enteric-coated capsule), or NR 300-600mg daily. Best taken in the morning. Combine with monthly IV NAD+ for maximum effect.
Ready to Start Oral NAD+?
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