Prepared from
your own blood.
PRF brings together platelets and a forming fibrin network. It is a biological preparation, not a one-size-fits-all product.
See how it worksULTRAFIBRIN® (PRF)
Hair. Face.
Hands.
A platelet-rich fibrin treatment prepared from your own blood. Explore the possibilities for hair and skin, understand the evidence, and decide with your clinician.
PERSONALIZED CONSULTATIONGILBERT, ARIZONA
From you.
For you.
For you.
FROM YOUR OWN BLOOD✦HAIR · FACE · HANDS✦INDIVIDUAL RESULTS
START HERE · THE KEY TAKEAWAYS
The essentials.
In a minute.
Prepared from
Three areas.
Different questions.
Hair growth, facial skin, and hand appearance need different assessments. The evidence is not equally strong for every area.
Understand the evidenceA response
reviewed over time.
Comparable photographs and clinical findings guide the next step. Your results and treatment plan are individual.
What to discussConsidering PRF? Start with a conversation about your goals
HAIR · FACE · HANDS
Before & after.
The fuller picture.
Explore the photographs together. Lighting, positioning, and treatment details all matter when interpreting a comparison. Individual results vary.
Open a photograph
Choose a comparison below.
Open a photograph
Choose a comparison below.
Drag anywhere on the photo to compare. Use the arrow keys when focused.
A treatment journey across repeat visits. Session count and follow-up interval to be confirmed with your clinician. Wetness, styling, and angle differ between photographs.
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01 Compare the same area02 Confirm treatment & timing03 Personal results vary
A treatment journey across repeat visits. Session count and follow-up interval to be confirmed with your clinician. Wetness, styling, and angle differ between photographs.Review the facial views together. Treatment details and follow-up interval to be confirmed with your clinician. Head tilt and lighting differ.The right hand is shown in both photographs. Position, lighting, and background differ. Treatment details and follow-up interval to be confirmed with your clinician.
ULTRAFIBRIN® · THE SCIENCE
Your blood.
A biological starting point.
Platelet-rich fibrin brings together components of your own blood. Follow the process, then explore why it is considered for each treatment area.
01 / COLLECT
It starts with your blood.
A clinician collects a small blood sample. Platelets carry signaling proteins involved in the body’s repair response.
02 / PREPARE
Separate the useful components.
A centrifuge separates blood components to prepare PRF. In an injectable preparation, a fibrin network forms as the material clots. The preparation method changes what is delivered.
03 / SIGNAL
A network. A local signal.
Fibrin is a temporary protein network that can hold platelets and support the release of their signaling proteins. Researchers study how those signals affect nearby cells; a cellular response does not guarantee a visible result.
04 / REVIEW
Measure the response over time.
Your clinician selects the treatment area and method, then reassesses with you. Comparable photographs and clinical findings help guide further treatment. The number of visits is individualized.
ONE PREPARATION FAMILY. DIFFERENT QUESTIONS.
Start with the follicle.
THE CONCERN
Changes in density, shedding, or the width of a part start with understanding why the hair is changing. Different causes need different care.
WHY PRF IS CONSIDERED
Platelets release signaling proteins involved in repair. For hair, researchers are studying whether a PRF preparation can support the environment around existing follicles.
Early clinical evidence
Small studies have reported changes in hair density and thickness in selected patterns of hair loss. They cannot predict your response or establish that new follicles will form.
2025 hair studyUnderstand the skin’s support.
THE CONCERN
Texture, fine lines, and changes in facial contours can have different causes. The treatment discussion starts with the change you want to address.
WHY PRF IS CONSIDERED
Fibroblasts are cells that make collagen, part of the skin’s supporting structure. In laboratory research, fluid PRF influenced fibroblast activity and collagen production.
Laboratory rationale + small clinical study
A small uncontrolled study of injectable PRF reported improvements in some skin measures and satisfaction. Wrinkle and texture changes were not statistically significant. This does not establish the same results for microneedling or topical application.
2020 facial skin studyLook beyond the surface.
THE CONCERN
Skin texture and the visibility of tendons or veins are different concerns. Your clinician can assess the skin and underlying volume before discussing an approach.
WHY PRF IS CONSIDERED
PRF is considered for its repair-signaling and fibrin biology. Skin-cell research offers a reason to investigate it, but a mechanism alone does not show how much the appearance of hands will change.
Rationale; hand outcomes not established by these studies
The laboratory and facial studies linked here do not establish hand-specific outcomes. Discuss that uncertainty, the exact treatment method, and the alternatives with your clinician.
2019 skin-cell laboratory studyThese sources study specific PRF preparations, not UltraFibrin as a brand. Injection and microneedling are different methods; your clinician will explain the proposed approach. A biological rationale does not guarantee a visible result.
THE SCIENCE · ONE LAYER DEEPER
A network.
A conversation between cells.
PRF is studied for the signals platelets release and the fibrin structure around them. Here is what those words mean.
Platelets carry signals.
Growth factors are proteins that help cells communicate during repair. They are signals—not new hair follicles or a supply of replacement skin.
Fibrin forms a network.
This temporary protein mesh is part of clotting. PRF preparations are studied for how that structure holds cells and releases signaling proteins.
Nearby cells may respond.
Fibroblasts help make the skin’s supporting matrix, including collagen. Their response to PRF in a laboratory supports investigation—not a guaranteed visible change.
The important distinction: biological activity explains why PRF is being studied. Human clinical studies are needed to learn whether that translates into meaningful benefit. Explore the laboratory sources
What are the growth factors researchers measure?
PDGF means platelet-derived growth factor; TGF-β1 means transforming growth factor beta 1; VEGF means vascular endothelial growth factor. Studies also measure signals such as EGF and IGF. These are research measurements, not a standardized ingredient label for your treatment.
Finding more of a signaling protein does not automatically mean a better cosmetic result. The preparation, tissue, delivery method, and patient response all matter. Read the growth-factor experiment
READ THE EVIDENCE, NOT JUST THE HEADLINE
Promising science.
Clear perspective.
A curated selection of primary studies, including encouraging findings and important limits. Open any study to see what was tested, what changed, and what it cannot tell us.
PRF is not PRP. Injectable PRF, solid PRF clots, platelet-rich fibrin matrix, and PRP are not interchangeable. These studies test particular preparations—not UltraFibrin® as a brand.
How it is delivered matters. An injection study does not establish the same outcome for topical use, microneedling, or radiofrequency microneedling.
HUMAN EVIDENCE · DEVELOPING
Existing follicles. Measurable questions.
Clinical studies suggest potential benefit for selected patterns of hair loss. A newer randomized comparison adds useful evidence, but it does not answer every question about suitability or durability.
2026 · Randomized comparisonA newer trial adds evidence for female-pattern hair loss.
- What was tested
- A multicenter trial compared i-PRF, PRP, and concentrated growth factors in women with female-pattern hair loss; 74 participants completed follow-up.
- What was found
- At 24 weeks, the i-PRF group had a greater increase in target-area hair count than the tested PRP group. Hair-diameter improvement did not differ significantly between groups.
- What to keep in mind
- Small treatment groups, a selected population, and no placebo group. This does not establish a benefit for every cause of hair loss or how long improvement lasts.
Li et al. · Journal of Dermatological Treatment · online April 2026
2025 · Uncontrolled clinical studyAn additional study reports improvement, with an important gap.
- What was tested
- A prospective study followed 30 people with androgenetic alopecia and inadequate responses to conventional treatment.
- What was found
- The authors reported improvements in clinical hair assessments, scalp symptoms, satisfaction, and quality-of-life measures at six months.
- What to keep in mind
- Without a control group, the study cannot isolate the treatment effect or establish superiority to medication. Its reported response rate is not your personal chance of success.
Yao et al. · Archives of Dermatological Research · 2025
2024 · Small case seriesEarly observations are encouraging, not a prediction.
- What was tested
- An uncontrolled series followed 11 women with female-pattern hair loss for 24 weeks after injectable PRF treatment.
- What was found
- Investigators reported more hair-bearing follicles in sampled areas and improvements in shedding and patient-reported fullness.
- What to keep in mind
- A very small study without a comparison group. More hair-bearing follicles does not mean that PRF created new follicles, and photographs cannot predict an individual response.
Sharma et al. · Journal of Cosmetic and Laser Therapy · 2024
HUMAN EVIDENCE · SMALL, MIXED STUDIES
Skin quality, studied one measure at a time.
Researchers have measured pores, spots, surface smoothness, and ultrasound changes. Improvement in one measure does not establish improvement in every concern.
2024 · Small ultrasound studyResearchers also measure beneath the visible surface.
- What was tested
- A single-center, open-label study of 20 volunteers examined different PRP and PRF preparations in specific facial regions using ultrasound.
- What was found
- The researchers reported increased lower-eyelid skin thickness on ultrasound after i-PRF treatment.
- What to keep in mind
- Different preparations were used in different regions, with a short follow-up and no untreated comparison. Ultrasound change is not the same as a proven lasting visible result or universal PRF superiority.
Majewska et al. · Dermatologic Therapy · 2024
2023 · Nonrandomized comparisonPRF versus PRP: a limited difference, not a lasting advantage.
- What was tested
- In a prospective facial study, 55 participants chose PRP or PRF rather than being randomly assigned.
- What was found
- Most measured regional outcomes did not differ between groups. An advantage in eye-corner smoothness with PRF at three months was no longer evident at six months.
- What to keep in mind
- Self-selection can bias comparisons. This study does not show that PRF is consistently better than PRP or that a short-term difference will persist.
Atsu et al. · Dermatologic Therapy · 2023
2020 · Uncontrolled injection studySome skin measures improved. Others did not clearly change.
- What was tested
- A prospective study assessed facial i-PRF injections in 11 women using a skin-analysis system and patient questionnaires.
- What was found
- Spot and pore measures and patient satisfaction improved. Changes in wrinkles and texture were not statistically significant.
- What to keep in mind
- Small sample, no control group, and limited follow-up. Findings from injections cannot be assumed for topical PRF, microneedling, or radiofrequency treatments.
Hassan et al. · Journal of Cosmetic Dermatology · 2020
HAND-SPECIFIC PRF OUTCOMES · UNCERTAIN
A different area needs its own evidence.
The PRF studies selected here do not establish cosmetic hand outcomes. The clinical conversation should distinguish skin texture from underlying volume and compare alternatives.
2024 · PRP trial — not PRFA related hand study shows why the product distinction matters.
- What was tested
- A randomized, single-blind study in 18 women compared PRP injections in one hand with saline injections in the other.
- What was found
- The study did not find a significant rejuvenation advantage for PRP over saline.
- What to keep in mind
- This was PRP, not PRF. It neither establishes PRF hand benefits nor directly tests whether PRF works. Laboratory and facial findings cannot fill that hand-specific evidence gap.
Pincelli et al. · Dermatologic Surgery · 2024
LABORATORY EVIDENCE · MECHANISM
Why the biology is worth investigating.
Laboratory studies help explain the rationale and why preparation matters. They cannot tell us the size, timing, or likelihood of a visible result in a patient.
2019 · Human cells in a laboratorySkin-supporting cells respond to fluid PRF in the lab.
- What was tested
- Researchers exposed cultured human dermal fibroblasts to fluid PRF or PRP.
- What was found
- The tested PRF preparation stimulated greater cell migration, proliferation, and collagen-matrix synthesis than the tested PRP preparation.
- What to keep in mind
- Cells in a dish are not a clinical treatment result. This does not establish how much collagen a patient will gain, visible wrinkle reduction, or clinical superiority.
Wang et al. · Journal of Cosmetic Dermatology · 2019
2017 · Preparation experimentThe way PRF is prepared changes what researchers measure.
- What was tested
- A laboratory study compared PRF clot preparations from eight blood donors and their effects on cultured gum-tissue fibroblasts.
- What was found
- Changing centrifugation speed and time altered growth-factor release and cellular responses in the tested preparations.
- What to keep in mind
- This is preparation research, not a hair, facial, or hand treatment trial. It does not establish one universally best clinical protocol.
Fujioka-Kobayashi et al. · Journal of Periodontology · 2017
2016 · Laboratory release studyA fibrin preparation can release signals over several days.
- What was tested
- Researchers compared growth-factor release from PRP, PRF, and advanced PRF made from six donors during a 10-day laboratory observation.
- What was found
- PRP released more of some factors early; PRF preparations showed continued release over the observation period. The patterns varied by preparation.
- What to keep in mind
- A laboratory release curve is not a measured treatment duration in your skin or scalp. It does not prove longer-lasting results than PRP.
Kobayashi et al. · Clinical Oral Investigations · 2016
Primary-source links checked September 10, 2026. Selected research, not an exhaustive review or a medical endorsement. This page is patient education; your clinician assesses suitability.
YOUR VISIT, STEP BY STEP
A plan that starts
with understanding.
Your goals, the treatment area, and your health history shape the conversation.
- 01 / UNDERSTAND
Find your starting point.
Discuss hair or skin changes, relevant health history, and previous treatments. Your clinician assesses what may be contributing.
- 02 / CONSIDER
Explore the options.
Discuss whether PRF belongs in your plan, what alternatives exist, and the benefits, uncertainty, cost, and risks.
- 03 / REVISIT
Review together.
Agree on consistent photographs and a follow-up plan. Reassess based on your experience and clinical findings.
ROOM FOR YOUR QUESTIONS
Clarity comes
before commitment.
Use your visit to understand the options, the limits, and what makes sense for you.
What is PRF?
Platelet-rich fibrin (PRF) is a preparation made from your own blood. It contains platelets and forms a fibrin network. UltraFibrin® is the treatment name used here. PRF methods vary, and platelet-rich plasma (PRP) is a different preparation. Research on one method does not establish outcomes for every method.
How do we choose the treatment area?
For hair, understanding the cause of shedding or thinning comes first. For face and hands, discuss whether the concern is skin texture, volume, or something else. Your clinician reviews your health history and the evidence, then compares the proposed method with alternatives.
When will I see a change?
There is no guaranteed response or fixed result date. Ask how your clinician will set review points, compare standardized photographs, and decide whether to continue or adjust your plan. A photograph alone cannot establish how many days have passed.
What should I know about comfort and recovery?
Blood collection, injections, and microneedling can be uncomfortable. Pain, redness, swelling, and bruising can occur; bleeding and infection are also possible. Injection risks depend on the area and include rare injury to blood vessels or surrounding tissue. Your clinician will discuss the specific risks, medicines, and aftercare relevant to your plan.
What does treatment cost?
Cost depends on the area, method, and proposed plan. Review the current LifeSpann menu and confirm what is included with your clinician. Discuss the complete plan cost before proceeding; a series is not automatically appropriate for everyone.
YOUR NEXT STEP
Let’s find what
makes sense for you.
Review your goals, ask your questions, and agree on a plan with your clinician.
Request a PRF consultation Explore the current treatment menu